[HTML][HTML] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis
NM El-Lakkany, WH El-Maadawy, SHS El-Din… - Asian Pacific journal of …, 2017 - Elsevier
Objective To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods The
impact of RA on stellate cell line (HSC-T6) proliferation, activation and apoptosis was
assessed along with its safety on primary hepatocytes. In vivo, rats were divided into:(i)
normal;(ii) thioacetamide (TAA)-intoxicated rats for 12 weeks;(iii) TAA+ silymarin or (iv) TAA+
RA. At the end of experiment, liver functions, oxidative stress, inflammatory and …
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods The
impact of RA on stellate cell line (HSC-T6) proliferation, activation and apoptosis was
assessed along with its safety on primary hepatocytes. In vivo, rats were divided into:(i)
normal;(ii) thioacetamide (TAA)-intoxicated rats for 12 weeks;(iii) TAA+ silymarin or (iv) TAA+
RA. At the end of experiment, liver functions, oxidative stress, inflammatory and …
[PDF][PDF] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis
Objective: To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods: The
impact of RA on stellate cell line (HSC-T6) proliferation, activation and apoptosis was
assessed along with its safety on primary hepatocytes. In vivo, rats were divided into:(i)
normal;(ii) thioacetamide (TAA)-intoxicated rats for 12 weeks;(iii) TAA+ silymarin or (iv) TAA+
RA. At the end of experiment, liver functions, oxidative stress, inflammatory and …
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods: The
impact of RA on stellate cell line (HSC-T6) proliferation, activation and apoptosis was
assessed along with its safety on primary hepatocytes. In vivo, rats were divided into:(i)
normal;(ii) thioacetamide (TAA)-intoxicated rats for 12 weeks;(iii) TAA+ silymarin or (iv) TAA+
RA. At the end of experiment, liver functions, oxidative stress, inflammatory and …
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